Periodontitis is an inflammatory disease of the supporting tissue of the teeth caused by the presence of subgingival Gram-negative bacteria, the red complex bacteria (RCB). The red complex bacteria include Porphyromonas gingivalis (P. gingivalis), Treponema denticola (T. denticola), and Tannerella forsythia (T. forsythia, formerly Bacteroides forsythus). These are recognized as the most important pathogens in adult periodontal disease. RCB multiply rapidly and re-colonization is a persistent threat.
Periodontitis is usually treated with scaling and root planing (SRP), which removes subgingival plaque mechanically. This procedure, even when meticulously performed, improves periodontal status, but is rarely effective in the complete removal of periodontal pathogens. If left untreated, periodontitis can increase periodontal pocket depth (PD) and bleeding on probing (BOP), and may lead to the spread of active infection to healthy sites. That being said, due to the limitations of scaling and root planing, adjunctive therapy is an essential part of treatment.
Minocycline HCl Microspheres Reduce Red-Complex Bacteria in Periodontal Disease Therapy (Goodson, 2007).
Arestin (minocycline HCl) Microspheres, 1 mg is a concentrated locally administered antibiotic that when used with scaling and root planing, is proven to maintain and control the chronic bacterial infection. Arestin is a site specific antibiotic meaning one carpule contains the correct dosage to treat one individual pocket at a time. The microspheres release antibiotic over time, targeting bacteria to reduce pocket depth, so gums can heal better than with scaling and root planing (SRP) alone1. Adding Arestin to SRP disrupts the pathogenic progression of periodontitis by specifically targeting the active infection.
Studies are show the hypothesis that RCBs are responsible for periodontal disease and that local antimicrobial therapy using MM + SRP effectively reduces numbers of RCBs and their proportions to a greater extent than SRP alone. (Goodson, 2007)
“Regardless of practice setting or employment arrangement, dental hygienists are expected to use their knowledge, skill and judgment to determine which treatment, product, drug, referral or combination of, is in the client’s best interest.”
(College of Dental Hygienists of Ontario, 2015)
ARESTIN® (minocycline hydrochloride) Microspheres, 1 mg. Prescribing Information. OraPharma; Horsham PA: 2015