BioGaia Study Highlights – Pregnancy gingivitis

Regular consumption of Lactobacillus reuteri-containing lozenges reduces pregnancy gingivitis: an RCT

Schlagenhauf U, Jakob L, Eigenthaler M, Segerer S, Jockel-Schneider Y, Rehn M.
J Clin Periodontol. 2016;43:948–954.

Demonstrates that L. reuteri Prodentis was effective in reduction of
pregnancy-associated gingivitis

Results

At follow-up, within two days after delivery:

  • The gingival index was categorized as 0 (no inflammation) in 79% and 37%, respectively, of the subjects in the probiotic and placebo group.
  • Gingival index score was significantly reduced: 0.2 vs. 0.7, p<0.0001
  • Plaque index score was significantly reduced: 0.2 vs. 0.6, p<0.0001
  • TNF-alfa in serum: no difference
Gingival Index scores

Conclusion

  • L. reuteri Prodentis significantly reduced pregnancy-associated gingivitis compared to placebo

Facts

  • Study design: Prospective, randomized, double-blind, placebo-controlled
  • Subjects: 45 healthy women in the third trimester of pregnancy and with gingivitis, adhering to their normal brushing habits
  • Dosage: 2 lozenges daily (4 x 108 CFU/day)
  • Mean duration, until delivery: 44 days
  • Primary endpoint: Reduction in gingival index during the study period
  • Secondary endpoints: Reduction in plaque index and serum levels of TNF-alfa

Further reading

  • Twetman S et al. Short-term effect of chewing gums containing probiotic Lactobacillus reuteri on the levels of inflammatory mediators in gingival crevicular fluid. Acta Odontologica Scandinavica 2009;67:19-24.
  • Teughels W et al. Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study. J Clin Periodontol. 2013; 40:1025–1035.
  • Tekçe M et al. Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: a 1-year follow-up study. J Clin Periodontol. 2015;42:363-372.
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