HANSAmed Geistlich Mucograft

Geistlich Mucograft®

1. What is Geistlich Mucograft®?
Geistlich Mucograft® is a unique 3D-collagen matrix designed specifically for soft-tissue regeneration as an alternative to autogenous soft-tissue grafts.
 
2. What is Geistlich Mucograft® made of?
Geistlich Mucograft® consists of porcine collagen and is specifically designed for soft-tissue regeneration. The matrix is comprised of a compact structure that provides stability while allowing open healing, paired with a spongy structure that supports blood clot stabilization and ingrowth of soft-tissue cells.
 
3. Is Geistlich Mucograft® resorbable?
The collagen in Geistlich Mucograft® is methodically replaced by newly formed soft tissue. The matrix is rapidly vascularized and colonized by soft-tissue cells. This leads to a good integration of the matrix without any signs of foreign body reaction1,2.
 
REFERENCES:
1. Rocchietta I, et al.: Int J Periodontics Restorative Dent 2012; 32(1): e34-40.
2. Ghanaati S, et al.: Biomed Mater 2011; 6(1): 015010.
 
4. Is Geistlich Mucograft® an alternative for free gingival graft (FGG) or for connective tissue graft (CTG)?
Geistlich Mucograft® can be used as an alternative to both a free gingival graft or a connective tissue graft (CTG) for increasing keratinized tissue1-3. Geistlich Mucograft® is also an alternative to CTG for use in recession coverage procedures4-6.
References:

  1. Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76.
  2. Lorenzo R, et al.: Clin. Oral Impl. Res 2012; 23(3): 316-24.
  3. Nevins M, et al.: Int J Periodontics Restorative Dent 2011; 31(4): 367-73.
  4. McGuire MK & Scheyer ET : J Periodontol 2010; 81(8): 1108-17.
  5. Cardaropoli D, et al.: J Periodontol 2012; 83(3): 321-28.
  6. Rotundo R & Pini-Prato G: Int J Periodontics Restorative Dent 2012; 32(4): 413-19.
5. Does Geistlich Mucograft® need to be treated prior to application to the defect?
Geistlich Mucograft® is ready to be applied directly to the defect and does not need treatment or hydration prior to application. Due to its excellent hydrophilicity, the matrix will hydrate quickly with the patient’s blood after placement in the defect.
 
6. Should Geistlich Mucograft® be handled/applied wet or dry?
Geistlich recommends handling and applying the material dry, as it is easy to trim and pre-suture.
 
7. Does Geistlich Mucograft® swell after placement?
Our measurements indicate that there is no additional swelling of the matrix following hydration (90 minute period examined)1.
References:

  1. Data on file, Geistlich Pharma AG, Wolhusen, Switzerland
8. Can Geistlich Mucograft® be stretched?
No. Geistlich Mucograft® has limited elongation properties and should always be sutured tension-free.
 
9. What suture should be used with Geistlich Mucograft®?
Published data shows different suturing techniques with Geistlich Mucograft®: non-resorbable1,2 and resorbable3, 0-51,2 and 0-64. There is no clinical evidence showing a benefit of one type of suture over another one when suturing Geistlich Mucograft®.
References:

  1. Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76.
  2. Herford AS, et al.: J Oral Maxillofac Surg 2010; 68(7): 1463-70.
  3. Cardaropoli D, et al.: J Periodontol 2012; 83(3): 321-28.
  4. McGuire MK & Scheyer ET : J Periodontol 2010; 81(8): 1108-17.
10. Which side of Geistlich Mucograft® should face the bone?
The compact structure should face outward, away from underlying bone, with the spongeous structure facing the bone or soft-tissue wound bed. No clinical or comparative data is available regarding the performance of Geistlich Mucograft® when placed with the compact structure facing the bone or soft-tissue wound bed.

 
11. How many layers of Geistlich Mucograft® should be used?
In the majority of the clinical cases reported and in all the studies performed with Geistlich Mucograft®, one matrix layer was used. Presently, clinical data is not available to prove that several layers of the device outperform a single layer of Geistlich Mucograft®.
 
12. Should Geistlich Mucograft® be placed directly over the bone or over the periosteum?
It depends on the indication:
1. Gain of keratinized tissue: Geistlich Mucograft® should be applied on a periosteal bed1,2 as direct blood supply is important. In open healing, the blood is supplied through the edges of the device from the surrounding tissue and from the periosteum.
2. Recession Coverage: Geistlich Mucograft® can be used partially or completely over bone.3-5 Blood is supplied through the edges of the device from the surrounding tissue and from the flap completely covering the matrix.
References:

  1. Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76.
  2. Lorenzo R, et al.: Clin Oral Impl Res 2012; 23(3): 316-24.
  3. McGuire MK & Scheyer ET : J Periodontol 2010; 81(8): 1108-17.
  4. Cardaropoli D, et al.: J Periodontol 2012; 83(3): 321-28.
  5. Rotundo R & Pini-Prato G: Int J Periodontics Restorative Dent 2012; 32(4): 413-19.
13. Should Geistlich Mucograft® be used submerged or in open healing situations?
It depends on the indication:
1. Gain of Keratinized Tissue: Open healing is recommended when Geistlich Mucograft® is used to increase the width of keratinized tissue. The innovative design of Geistlich Mucograft® allows excellent healing in open healing situations1.
2. Recession Coverage: Geistlich Mucograft® should remain completely submerged under the flap to avoid premature resorption of the collagen.2-4 Direct blood supply is important.
References:

  1. Sanz M, et al.: J Clin Periodontol 2009; 36(10): 868-76.
  2. McGuire MK & Scheyer ET: J Periodontol 2010; 81(8): 1108-17.
  3. Cardaropoli D, et al.: J Periodontol 2012; 83(3): 321-28.
  4. Rotundo R & Pini-Prato G: Int J Periodontics Restorative Dent 2012; 32(4): 413-19.
14. Are antibiotics needed after treatment with Geistlich Mucograft®?
After treatment with Geistlich Mucograft®, please follow the same postsurgical management that is usually applied with connective tissue grafts or free gingival grafts.
CAUTION

Federal law restricts these devices to sale by or on the order of a dentist or physician.

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