Geistlich Bio-Gide® is the leading collagen membrane in North America for oral tissue regeneration.1,2 It is used in combination with a bone substitute such as Geistlich Bio-Oss® or Geistlich Bio-Oss Collagen®. Geistlich Bio-Gide® integrates with surrounding tissues to protect the initial coagulum. With its unique bilayer structure, Geistlich Bio-Gide® not only prevents ingrowth of soft tissue into the augmented site, but then optimally degrades to allow for the cascade of biologic events leading to regeneration.5,6 It is the sum of these characteristics that defines the biofunctionality of Geistlich Bio-Gide® and is the basis for its long-term clinical success.
For additional information on the biofunctionality of Geistlich Bio-Gide® please review the ‘Downloads’ section on the right-hand side of this page.
Geistlich Bio-Gide® is naturally resorbable, therefore a second surgery for removal of the membrane is not required. As it simplifies the surgical technique, and exhibits excellent wound healing properties3,4, Geistlich Bio-Gide® has fundamentally changed dental bone regeneration.
Leading clinicians rely on Geistlich Bio-Gide® for:
- Excellent tissue integration5,6 and strongly enhanced bone regeneration compared to using a bone substitute alone.7,8
- Native collagen structure results in fewer dehiscences compared with other available membranes.3,4,9
- Fully resorbable, no second surgery required for membrane removal.
- Aesthetically stable results after 5-9 years.10
- Long-term data over 12 to 14 years demonstrates predictable results in Guided Bone Regeneration (GBR) treatments when Geistlich Bio-Gide® is used in combination with Geistlich Bio-Oss®11.
Geistlich Bio-Gide® was originally developed to eliminate dehiscences and improve handling characteristics. Today, Geistlich Bio-Gide® provides the optimal requirements for bone regeneration and is the leading collagen membrane, validated by 18 years of successful clinical use in more than two million patients and documented in more than 250 scientific publications.12
Documented, Reliable, Experienced
Geistlich Bio-Gide® is ideally suited to guide your daily regenerative needs. Throughout our long history of quality and innovation, Geistlich Biomaterials have been intentionally designed for each application. In the patented production of Geistlich Bio-Gide®, the native collagen fibers are preserved in a non cross-linked porcine derived collagen membrane. The unique bilayer structure is designed with both a cell occlusive and a fibrous surface which protect the site during healing and allow for the deposition of proteins.1
This results in early vascularization and subsequent bone formation.2, 4, 12 The preservation of native fibers ensures that vital building blocks are present to promote the initial biologic processes of cell adhesion and proliferation.14-16 Geistlich Bio-Gide® integrates with surrounding tissues to protect the initial coagulum and then optimally degrades to allow for the cascade of biologic events leading to regeneration.2-4 It is the sum of these characteristics that define the biofunctionality of Geistlich Bio-Gide® and is the basis for its long-term clinical success.
The image on the left demonstrates the attachment and proliferation of fibroblasts on the cell occlusive surface of Geistlich Bio-Gide®.
The image on the right demonstrates the attachment and proliferation of osseous cells on the fibrous surface.
The original by design
Bio-Gide® redefined predictablity in guided tissue/bone regeneration – and still sets the standard.
As the first membrane of its kind, Geistlich Bio-Gide® was originally developed to eliminate problems associated with soft tissue dehiscences and improve handling characteristics. Today, with decades of clinical experience and supported by more than 100 publications, the original Geistlich Bio-Gide® is the reliable choice for:
• Optimal soft-tissue healing5, 6
• Excellent tissue integration4, 9
• Early and complete vascularization2, 4
• Undisturbed bone regeneration2, 12
• Predictable outcomes in the esthetic zone10
• Ease of use in a wide range of indications
The smooth side of Geistlich Bio-Gide®
prevents soft tissue from growing into the defect
(scanning electronic microscope image, 250x,
Dr. Bufler, Wolhusen).
The porous side of Geistlich Bio-Gide® serves as
a framework for bone cells and blood vessels.3–5
(scanning electronic microscope image, 10,000x,
Dr. Bufler, Wolhusen).
For optimal bone formation and soft-tissue healing,
a barrier function is just the beginning.
Geistlich Bio-Gide® is comprised of type I and III collagens, the predominant collagen constituents of human oral tissues, which provide collagen signals and fibril guidance for healing cells.13 It is designed with a smooth, compact cell occlusive layer which is an ideal catalyst for the attachment of fibroblasts.2, 4-13
This unique surface and its similarity to periosteum guides fibroblasts to lay down and align on the surface, creating a functional “biologic membrane” for favourable healing of the gingival tissue.
The fibrous layer facing the defect acts as a guide for angiogenic and osteoblastic cells which become the foundation2, 4-12 for optimal bone formation and regenerative healing. Geistlich Bio-Gide® is indicated in the following therapeutic areas:
- Extraction sockets
- Ridge augmentation
- Periodontal defects
- Sinus floor elevation
For clinical indications where both a physical matrix and a barrier are needed, Geistlich Bio-Oss® provides the volume and space preservation necessary to make it a natural companion to Geistlich Bio-Gide®.*
Advantages of early vascularization
Early vascularization encourages bone and periodontal regeneration
The unique properties of Geistlich Bio-Gide® allow for early vascularization of the membrane
and play a central role in the angiogenesis fundamental to new bone and periodontal tissue
Membrane vascularization is a key step in bone and periodontal regeneration with Geistlich Bio-Gide®:
Advantages of early vascularization
Optimal bone formation is crucial for predictable long-term results, leading to successful hard
tissue contour and soft-tissue stability.10
Predictable esthetic outcomes
Case: Prof. Dr. Buser, Berne (Individual results may vary).
With a visible buccal dehiscence, the implant has been placed in an optimal position.
Geistlich Bio-Oss® is mixed with blood and placed in the defect.
Geistlich Bio-Gide® is applied in two layers to enhance stabilization of the augmentation material.
8 weeks post-operative result. The augmentation site with an esthetically pleasing contour and soft-tissue healing.
Case: PD Dr. Jung, Zurich
Visible bony defect after
Following implant placement, the defect
is filled with Geistlich Bio-Oss®.
Placement of Geistlich Bio-Gide® over the augmentation material.
Soft tissue healing and excellent
Predictable bone formation with Geistlich Bio-Gide®
In a randomized controlled clinical trial, patients treated with Geistlich Bio-Gide® showed significantly greater
defect fill than those with an experimental cross-linked membrane. Insufficient bone regeneration was associated
with the cross-linked membrane having a prolonged resorption time, while substantial defect fill was observed
with Geistlich Bio-Gide®11.
CAUTION: Federal law restricts these devices to sale by or on the order of a dentist or physician. Indications: Geistlich Bio-Oss®, Geistlich Bio-Oss Collagen® and Geistlich Bio-Oss Pen® are indicated for the following uses: Augmentation or reconstructive treatment of the alveolar ridge; Filling of periodontal defects; Filling of defects after root resection, apicoectomy, and cystectomy; Filling of extraction sockets to enhance preservation of the alveolar ridge; Elevation of the maxillary sinus floor; Filling of periodontal defects in conjunction with products intended for Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR); and Filling of peri-implant defect in conjunction with products intended for GBR. Warnings: Possible complications which may occur with any surgery include swelling at the surgical site, flap sloughing, bleeding, local inflammation, bone loss, infection or pain. As Geistlich Bio-Oss Collagen® contains collagen, in very rare circumstances cases of allergic reactions, may occur.Indications:Geistlich Bio-Gide® and Geistlich Bio-Gide® Perio are indicated for the following uses: Augmentation around implants placed in immediate and delayed extraction sockets; Localized ridge augmentation for later implantation; Alveolar ridge reconstruction for prosthetic treatment; Filling of bone defects after root resection, cystectomy, removal of retained teeth; GBR in dehiscence defects; and GTR procedures in periodontal defects. Warnings: As it is a collagen product, allergic reactions may not be totally excluded. Possible complications which may occur with any surgery include swelling at the surgical site, flap sloughing, bleeding, dehiscence, hematoma, increased sensitivity and pain, bone loss, redness, and local inflammation. Indications: Geistlich Mucograft® is indicated for the following uses: Covering of implants placed in immediate or delayed extraction sockets, localized gingival augmentation to increase keratinized tissue (KT) around teeth and implants, alveolar ridge reconstruction for prosthetic treatment, recession defects for root coverage. Warnings: As Geistlich Mucograft® is a collagen product allergic reactions may not be totally excluded. Possible complications which may occur with any surgery include swelling at the surgical site, flap sloughing, bleeding dehiscence, hematoma, increased sensitivity and pain, bone loss, redness and local inflammation. For more information on contraindications, precautions, and directions for use, please refer to the Geistlich Bio-Oss®, Geistlich Bio-Oss Collagen®, Geistlich Bio-Oss Pen®, Geistlich Bio-Gide®, Geistlich Bio-Gide® Perio and Geistlich Mucograft®. Instructions for use at: www.geistlich-na.com/ifu
CAUTION: Federal law restricts these devices to sale by or on the order of a dentist or physician.
1 Bertolo A et al., Eur Spine J 2012; Aug(6): 826-38 – 2 Schwarz F et al., Clin Oral Implants Res 2008; 19(4): 402-415 3 Von Arx T et al., Clin Oral Implants Res 2006; 17(4): 359-66 – 4 Schwarz F et al., Clin Oral Implants Res 2006; 17(4): 403-409 5 Becker J et al., Clin Oral Implants Res 2009; 20(7): 742-749 – 6 Tal H et al., Clin Oral Implants Res 2008; 19(3): 295-302 7 Wang Y et al., Ann N Y Acad Sci 2007; 1117(Aug): 1-11 – 8 Jerosch J, Bader A, Uhr G, Knochen. 2002 Georg Thieme Verlag. ISBN 3-13-132921-1 9 Rothamel D et al., Clin Oral Implants Res 2005; 16(3): 369-378 – 10 Buser D et al., J Periodontol 2011; 82(3): 342-349 – 11 Annen BM et al., Eur J Oral Implantol 2011; 4(2): 87-100 12 Zitzmann NU et al., Int J Oral Maxillofac Implants 1997; 12(6): 844-852 13 Chavier C et al., Journal de Biologie Buccale 1981; 9(3): 271-77 14 Tran KT et al., Wound Repair Regen 2004; 12(3): 262-68 15 Pilcher BK et al., J Cell Biol 1997; 137(6): 1445-57 16 Rothamel D et al., Clin Oral Impl Res 2004; 15(4): 443-49
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3. Tal H, et al.: Clin. Oral Implants Res 2008; 19: 295-302.
4. Zitzmann NU, et al.: Int J Oral Maxillofac Implants 1997; 12: 844-52.
5. Schwarz F, et al.: Clin Oral Implants Res 2006; 17: 403-09.
6. Schwarz F, et al.: Clin Oral Implants Res 2008; 19(4): 402-15.
7. Perelman-Karmon et al.: Int J Periodontics Restorative Dent 2013, 32(4): 459-65.
8. Wallace SS, et al.: Int J Periodontics Restorative Dent 2005; 25(6): 551-59.
9. Becker J, et al.: Clin. Oral Implants Res 2009; 20(7): 742-93.
10. Buser D, et al.: J Periodontol 2011; 82(3): 342-49.
11. Jung RE, et al.: Clin Oral Implants Res. 2013; 24(10):1065-73.
12. Pubmed September 2013. Search Term: Bio-Gide.