Biofunctionality: Based on Science
What Nature Inspires, Geistlich Engineers.
Intentional design and the preservation of biologically natural structures are key elements in the development of Geistlich Biomaterials and the accompanying dental applications. Through unique, proprietary technology used during manufacturing, nature’s complex tissues are carefully processed to preserve biologic cues that enable optimal tissue integration.1,2
Biologically Natural Structures –
The crystalline structure of Geistlich Bio-Oss® and the Type I & III bi-layer collagen structures of Geistlich Bio-Gide® and Geistlich Mucograft® retain natural forms, allowing the body to accept these biomaterials as native. The surface of Geistlich Bio-Oss® supports the adsorption of proteins that enables adhesion of bone-forming cells.3-5 Using specific surface receptors, cells bind directly to Geistlich collagens. Geistlich Mucograft® is designed to provide a requisite, reinforcing matrix and a signaling source for regenerative wound healing. Fibroblasts respond to the collagen by attaching, orienting, and producing new collagen integration. Collagen research suggests that in such scaffolds, endothelial progenitor cells are activated for angiogenesis, and the intact collagen fibrils serve as conduits for endothelial cells and the formation of vascular channels of nutrition. These vascular channels are surrounded with perivascular mesenchymal stem cells with anti-inflammatory properties.6-9 Due to these properties, the clinical result observed with Geistlich Mucograft® is optimal soft tissue regeneration rather than soft tissue repair. 10-13
Nature’s Capacity for Healing.
The human body possesses the capacity for regenerative wound healing. The natural structures of Geistlich Bio-Oss®, Geistlich Bio-Gide®, and Geistlich Mucograft® enhance the biologic cascade of healing events by attracting and delivering essential serum proteins. The result is complete tissue integration that encourages regenerative healing.
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- Schwarz F, et al., Clin. Oral Implants Res. 2006; 17: 403-409
- Taguchi Y, et al., Biomaterials. 2005 Nov;26(31):6158-66
- Galindo-Moreno P, et al., Clin Oral Implants Res. 2014 Mar; 25(3):366-71. doi: 10.1111/clr. 12112 Epub 2013 Jan 28
- Araújo MG, et al., Clin Oral Implants Res. 2010 Jan; 21(1):55-64
- Nien Y, et al., Wound Repair and Regeneration. 2003; 11(5), 380-385
- Tran KT, et al., Wound Repair and Regeneration, 2004; 12(3), 262-268
- Davis GE, et al., Biochemical and Biophysical Research Communications. 1992 182(3), 1025-1031
- Tran KT, et al., Journal of Dermatological Science. 2005; 40(1), 11-20
- Badylak S, et al., 2009. Acta Biomaterialia, 5(1), 1-13
- Ghanaati S, et al. Biomed Mater. 2011 Feb; 6(1): 015010
- Rocchietta I, et al., Int J Periodontics Restorative Dent. 2012 Feb; 32(1):e34-40
- Nevins M, et al. Int J Periodontics Restorative Dent. 2011 Jul-Aug; 31(4):367-73
- Berglundh T, Lindhe J, Clin Oral Implants Res 1997; 8(2): 117–124.
- Becker J et al., Clin. Oral Implants Res. 2009; 20(7): 742–93
- Schwarz F et al., Clin Oral Implants Res. 2014 Sep;25(9):1010–5
- Weibrich G et al., Mund Kiefer Gesichtschirurg 4, 2000; 148–152
- Degidi M et al., Oral Dis. 2006 Sep; 12(5): 469–475
- Mordenfeld A et al., Clin Oral Implants Res. 2010 Sep;21(9):961–70
- Jung R et al., Clin Oral Implants Res. 2013 Oct;24(10):1065–73
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